Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 4/20 | 0.54 |
| ▸ | MMP12 | P39900 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585515 | 0.90 | SIGMAR1 (0.45) | ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL27492664 | 0.80 | FDFT1 (0.57) | FDFT1MMP12MMP2MMP9MMP13 | |
| SCHEMBL13061753 | 0.79 | MAOB (0.46) | ALDH1A1 | |
| SCHEMBL159574 | 0.79 | TP53 (0.58) | FFAR1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8283176 | 0.79 | TP53 (0.58) | FFAR1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9285880 | 0.78 | ALDH1A1 (0.50) | ALDH1A1CYP1A2 | |
| SCHEMBL1976468 | 0.78 | ALDH1A1 (0.50) | ALDH1A1CYP1A2 | |
| SCHEMBL8719636 | 0.77 | FDFT1 (0.54) | FDFT1MMP12MMP2MMP9MMP13 | |
| SCHEMBL8621642 | 0.77 | FDFT1 (0.54) | FDFT1MMP12MMP2MMP9MMP13 | |
| SCHEMBL27800230 | 0.77 | FDFT1 (0.54) | FDFT1MMP12MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016128924-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF NEP INHIBITORS | NOVARTIS AG (CH) | 2016-08-18 | — | — | WO | disclosed |