Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 6/20 | 0.63 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.54 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17979699 | 0.79 | NUDT1 (0.72) | NUDT1HRH4ROCK1 | |
| SCHEMBL18019880 | 0.76 | NUDT1 (0.53) | NUDT1HRH4DPP4CHRM3PDE4A | |
| SCHEMBL1775482 | 0.73 | NUDT1 (0.76) | NUDT1HRH4CHRM3PDE4APDE4B | |
| SCHEMBL17979668 | 0.73 | NUDT1 (0.63) | NUDT1HRH4CHRM3PDE4APDE4B | |
| SCHEMBL17979683 | 0.73 | NUDT1 (0.61) | NUDT1HRH4ROCK1 | |
| SCHEMBL17979710 | 0.72 | NUDT1 (0.57) | NUDT1HRH4CHRM3PDE4APDE4B | |
| SCHEMBL17979782 | 0.70 | NUDT1 (0.46) | NUDT1HRH4DPP4CHRM3PDE4A | |
| SCHEMBL17979705 | 0.70 | NUDT1 (0.67) | NUDT1HRH4CHRM3PDE4APDE4B | |
| SCHEMBL17979722 | 0.70 | NUDT1 (0.67) | NUDT1HRH4CHRM3PDE4APDE4B | |
| SCHEMBL20114450 | 0.70 | NUDT1 (0.59) | NUDT1HRH4CHRM3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
| WO-2016128140-A1 | PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | MERCK PATENT GMBH (DE) | 2016-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MTHFD1, TYMS, DPYD | NUDT1 10/4885HRH4 2404/4885DPP4 3898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.