Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 5/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.47 |
| ▸ | CHIT1 | Q13231 | 3/20 | 0.41 |
| ▸ | CHIA | Q9BZP6 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 5/20 | 0.39 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18019881 | 0.89 | HRH4 (0.49) | NUDT1HRH4ATMPIK3C3 | |
| SCHEMBL17979757 | 0.84 | HRH4 (0.48) | NUDT1HRH4ATM | |
| SCHEMBL17979700 | 0.84 | HRH4 (0.48) | NUDT1HRH4ATM | |
| SCHEMBL17979784 | 0.84 | HRH4 (0.48) | NUDT1HRH4ATM | |
| SCHEMBL18019883 | 0.83 | HRH4 (0.48) | NUDT1HRH4ATMPIK3C3 | |
| SCHEMBL17979673 | 0.83 | HRH4 (0.48) | NUDT1HRH4ATM | |
| SCHEMBL20114232 | 0.80 | NUDT1 (0.55) | NUDT1HRH4KCNH2 | |
| SCHEMBL17979752 | 0.80 | NUDT1 (0.55) | NUDT1HRH4KCNH2 | |
| SCHEMBL18019806 | 0.80 | NUDT1 (0.55) | NUDT1HRH4KCNH2 | |
| SCHEMBL18019876 | 0.80 | NUDT1 (0.55) | NUDT1HRH4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
| WO-2016128140-A1 | PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | MERCK PATENT GMBH (DE) | 2016-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MTHFD1, TYMS, DPYD | NUDT1 10/4885HRH4 2404/4885CHIT1 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.