Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | PRNP | P04156 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18020580 | 0.86 | MEN1 (0.56) | BACE1MEN1KMT2AALDH1A1POLB | |
| SCHEMBL17550095 | 0.69 | ACMSD (1.00) | MEN1KMT2ARXFP1ALDH1A1POLB | |
| SCHEMBL16772467 | 0.69 | MEN1 (0.72) | MEN1KMT2ARXFP1ALDH1A1POLB | |
| SCHEMBL24087903 | 0.68 | RXFP1 (0.77) | MEN1KMT2ARXFP1ALDH1A1POLB | |
| SCHEMBL17550100 | 0.67 | ACMSD (1.00) | MEN1KMT2ARXFP1ALDH1A1POLB | |
| SCHEMBL5698591 | 0.67 | MEN1 (0.60) | MEN1KMT2AALDH1A1POLBNPSR1 | |
| SCHEMBL26847418 | 0.67 | RXFP1 (0.85) | MEN1KMT2ARXFP1ALDH1A1POLB | |
| SCHEMBL21484713 | 0.67 | ABL1 (0.68) | MEN1KMT2AALDH1A1USP2KDM4E | |
| SCHEMBL837694 | 0.67 | GAA (0.68) | MEN1KMT2APOLBNPSR1USP2 | |
| SCHEMBL23850319 | 0.66 | KMT2A (0.82) | MEN1KMT2ARXFP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180169098-A1 | SMALL MOLECULES TARGETING HIV-1 NEF | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-06-21 | — | — | US | disclosed |
| US-20160235750-A1 | SMALL MOLECULES TARGETING HIV-1 NEF | University of Pittsburgh - of the Commonwealth Sys tem of Higher Education (US) | 2016-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169098-A1 | SMALL MOLECULES TARGETING HIV-1 NEF | SLC43A1, NAT1, CD4 | BACE1 2103/4885MEN1 4429/4885KMT2A 2565/4885 |
| US-20160235750-A1 | SMALL MOLECULES TARGETING HIV-1 NEF | SLC43A1, NAT1, CD4 | BACE1 2103/4885MEN1 4429/4885KMT2A 2565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.