Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14731236 | 0.80 | TRIM24 (0.40) | TRIM24CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL14726024 | 0.77 | TRIM24 (0.38) | TRIM24CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL764049 | 0.69 | HTR1A (0.46) | TRIM24CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL763180 | 0.66 | SRD5A1 (0.52) | TRIM24CYP11B1CYP11B2CYP19A1ALDH1A1 | |
| SCHEMBL12057333 | 0.66 | CYP11B1 (0.52) | TRIM24CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL22491598 | 0.65 | POLB (0.41) | CYP11B1CYP11B2CYP3A4CYP19A1KDM4E | |
| SCHEMBL16431883 | 0.64 | CYP11B1 (0.56) | TRIM24CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL6074490 | 0.64 | CYP11B1 (0.50) | TRIM24CYP11B1CYP11B2CYP3A4CYP19A1 | |
| SCHEMBL885034 | 0.64 | NOTUM (0.49) | DRD2HTR2CDRD3SIGMAR1 | |
| SCHEMBL31528079 | 0.64 | ALDH1A1 (0.37) | PTGS2LMNAKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3056207-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2016-08-17 | — | — | EP | disclosed |