Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27820911 | 0.81 | ALDH1A1 (0.46) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL18023110 | 0.81 | ALDH1A1 (0.46) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL18023034 | 0.80 | ALDH1A1 (0.60) | TLR8KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL167603 | 0.78 | TDP1 (0.55) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL180365 | 0.78 | TLR8 (0.65) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL18023061 | 0.77 | TLR8 (0.49) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL16654428 | 0.77 | ALDH1A1 (0.58) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL177896 | 0.77 | TLR8 (0.58) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL17690407 | 0.77 | TLR8 (0.49) | TLR8BTKKDM4EALDH1A1HPGD | |
| SCHEMBL31378885 | 0.77 | TLR8 (0.58) | TLR8BTKKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429568-B1 | MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS | ENANTA PHARM INC (US) | 2016-08-17 | — | — | EP | disclosed |