SCHEMBL18024038

SCHEMBL18024038

OCCOCCCN1CCCCC1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 16/20 0.53
SLC6A2 P23975 2/20 0.50
HRH1 P35367 2/20 0.50
CHRM2 P08172 1/20 0.50
ADRA2C P18825 1/20 0.50
SLC6A4 P31645 1/20 0.50
SLC6A3 Q01959 1/20 0.50
KCNH2 Q12809 1/20 0.50
CACNA1C Q13936 1/20 0.50
SCN5A Q14524 1/20 0.50
CHRM4 P08173 1/20 0.49
HTR2C P28335 1/20 0.49
HTR7 P34969 1/20 0.49
TMEM97 Q5BJF2 1/20 0.49
SIGMAR1 Q99720 1/20 0.49
CYP1A2 P05177 1/20 0.44
MAPK1 P28482 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ACHE P22303 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12371264 0.98 HRH3 (0.50) HRH3SLC6A2HRH1CHRM2ADRA2C
SCHEMBL22266158 0.94 HRH3 (0.48) HRH3SLC6A2HRH1CHRM2ADRA2C
SCHEMBL18024010 0.92 HRH3 (0.53) HRH3SLC6A2HRH1CHRM2ADRA2C
SCHEMBL4650639 0.91 HRH3 (0.48) HRH3SLC6A2HRH1CHRM2ADRA2C
SCHEMBL10509584 0.91 HRH3 (0.48) HRH3SLC6A2HRH1CHRM2ADRA2C
SCHEMBL18024004 0.89 HRH3 (0.50) HRH3SLC6A2HRH1CHRM2ADRA2C
SCHEMBL10077337 0.89 MEN1 (0.48) HRH3CYP1A2MAPK1SMN1; SMN2
SCHEMBL1469605 0.89 TSHR (0.48) HRH3HRH1CHRM2ADRA2CKCNH2
SCHEMBL5281401 0.89 HRH3 (0.62) HRH3SLC6A2HRH1CHRM2ADRA2C
SCHEMBL18024040 0.88 HRH3 (0.50) HRH3SLC6A2HRH1CHRM2ADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016130968-A1 BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR YALE UNIVERSITY (US) 2016-08-18 WO disclosed