SCHEMBL18025323

SCHEMBL18025323

COc1ccc(C(c2ccc(OC(=O)c3ccc(Cc4ccc(C(C)=O)cc4)cc3)cc2)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 1/20 0.47
▸ KMT2A Q03164 8/20 0.45
▸ LMNA P02545 2/20 0.44
▸ CYP1A2 P05177 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ CYP2C19 P33261 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ MAPT P10636 2/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ PRSS1 P07477 2/20 0.42
▸ ACR P10323 2/20 0.42
▸ GLA P06280 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ GFER P55789 1/20 0.42
▸ NPC1 O15118 1/20 0.41
▸ EPHX2 P34913 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ NR1H4 Q96RI1 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12762422 0.93 KMT2A (0.50) MAOBKMT2ALMNACYP1A2CYP2C9
SCHEMBL15764240 0.89 MAPT (0.49) MAOBKMT2ALMNACYP1A2CYP2C9
SCHEMBL12895879 0.87 KMT2A (0.59) KMT2ALMNACYP1A2CYP2C9CYP2C19
SCHEMBL12762440 0.87 KMT2A (0.59) KMT2ALMNACYP1A2CYP2C9CYP2C19
SCHEMBL13324841 0.86 KMT2A (0.49) MAOBKMT2ALMNACYP1A2CYP2C9
SCHEMBL13258482 0.86 KMT2A (0.47) MAOBKMT2ALMNACYP1A2CYP2C9
SCHEMBL12376965 0.83 KMT2A (0.54) KMT2ALMNACYP1A2CYP2C9CYP2C19
SCHEMBL12199953 0.82 MAPT (0.48) MAOBKMT2ALMNAMAPTALDH1A1
SCHEMBL13161732 0.81 MAPT (0.61) KMT2ALMNACYP1A2CYP2C9CYP2C19
SCHEMBL17753751 0.81 KMT2A (0.46) MAOBKMT2ALMNACYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9651879-B2 Electrophotographic photosensitive member, method of producing the electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-05-16 — — US disclosed
US-20160238957-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF PRODUCING THE ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2016-08-18 — — US disclosed
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