Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402476 | 0.87 | HRH4 (0.50) | HRH4HRH3SMN1; SMN2HTTNSD2 | |
| SCHEMBL12269865 | 0.83 | HRH4 (0.46) | HRH4HRH3SMN1; SMN2HTTNSD2 | |
| SCHEMBL18032426 | 0.75 | HRH4 (0.44) | HRH4HRH3HTT | |
| SCHEMBL2405631 | 0.74 | MAPT (0.45) | HRH4HTT | |
| SCHEMBL10667948 | 0.73 | KDM4E (0.64) | HRH4PIK3CAMTORHTTNSD2 | |
| SCHEMBL29969981 | 0.72 | HRH4 (0.53) | HRH4HRH3SMN1; SMN2HTT | |
| SCHEMBL20605140 | 0.72 | HRH4 (0.53) | HRH4HRH3SMN1; SMN2HTT | |
| SCHEMBL14829239 | 0.70 | HRH4 (0.50) | HRH4HRH3 | |
| SCHEMBL3146942 | 0.70 | HRH4 (0.54) | HRH4SMN1; SMN2 | |
| SCHEMBL30593370 | 0.70 | HRH4 (0.48) | HRH4HRH3SMN1; SMN2HTTNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545058-B1 | TETRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS INHIBITORS OF HISTAMINE RECEPTORS | KALYPSYS INC (US) | 2016-08-24 | — | — | EP | disclosed |