Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038740 | 0.92 | RET (0.50) | RETGPR119USP30SPRMEN1 | |
| SCHEMBL18038812 | 0.81 | GPR119 (0.46) | RETGPR119USP30SPRMEN1 | |
| SCHEMBL24884312 | 0.77 | NR1H2 (0.50) | MEN1USP2HPGDKMT2ADDB1 | |
| SCHEMBL22169156 | 0.77 | NR1H2 (0.50) | MEN1USP2HPGDKMT2ADDB1 | |
| SCHEMBL400513 | 0.77 | NR1H2 (0.50) | MEN1USP2HPGDKMT2ADDB1 | |
| SCHEMBL608991 | 0.77 | NR1H2 (0.50) | MEN1USP2HPGDKMT2ADDB1 | |
| Hydrochloric Acid SCHEMBL7149386 | 0.75 | NR1H2 (0.49) | MEN1USP2HPGDKMT2ADDB1 | |
| SCHEMBL18038692 | 0.75 | GPR119 (0.47) | RETGPR119SPRHPGDPREP | |
| SCHEMBL18038733 | 0.72 | GPR119 (0.52) | RETGPR119USP30MEN1USP2 | |
| SCHEMBL15095875 | 0.71 | GPR119 (0.49) | RETGPR119USP30MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |
| EP-3262036-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016138114-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | WO | disclosed |