SCHEMBL608991

SCHEMBL608991

CC(C)(C)OC(=O)N1C[C@H]2CC[C@@H](C1)N2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.50
CHRNB2 P17787 6/20 0.48
CHRNA3 P32297 6/20 0.48
CHRNA4 P43681 6/20 0.48
CHRNB3 Q05901 6/20 0.48
CHRNA6 Q15825 6/20 0.48
HPGD P15428 1/20 0.45
DDB1 Q16531 1/20 0.45
CRBN Q96SW2 1/20 0.45
USP2 O75604 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
RECQL P46063 1/20 0.43
EPHX1 P07099 1/20 0.43
MAPT P10636 2/20 0.42
KDM4E B2RXH2 1/20 0.42
THRB P10828 1/20 0.42
CHRM2 P08172 1/20 0.42
CHRM1 P11229 1/20 0.42
CHRM3 P20309 1/20 0.42
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL400513 1.00 NR1H2 (0.50) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL24884312 1.00 NR1H2 (0.50) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL22169156 1.00 NR1H2 (0.50) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
Hydrochloric Acid SCHEMBL7149386 0.98 NR1H2 (0.49) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL18081207 0.93 NR1H2 (0.47) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL1979623 0.91 NR1H2 (0.56) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL25409415 0.91 NR1H2 (0.56) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL994561 0.91 NR1H2 (0.56) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
Hydrochloric Acid SCHEMBL18038711 0.91 NR1H2 (0.43) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL4321473 0.90 HPGD (0.48) NR1H2CHRNB2CHRNA3CHRNA4CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137676-A1 PIPERAZINE SUBSTITUTED PHENOL DERIVATIVE AND USE THEREOF CHENGDU MFS PHARMA. CO., LTD. (CN) 2026-05-21 US disclosed
EP-4709371-A1 SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT Merck Sharp & Dohme LLC (US) 2026-03-18 EP disclosed
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2026-02-12 US disclosed
US-12545659-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2026-02-10 US disclosed
EP-4631948-A1 NOVEL TRICYCLIC COMPOUND AS KRAS G12D INHIBITOR, AND USE THEREOF SK Biopharmaceuticals Co., Ltd. (KR) 2025-10-15 EP disclosed
US-20250276964-A1 Benzisoxazole Derivatives and Uses thereof NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2025-09-04 US disclosed
US-12371426-B2 Pyridazine derivatives as SMARCA2/4 degraders AURIGENE DISCOVERY TECH LTD (IN) 2025-07-29 US disclosed
US-12331026-B2 Sulfonamido derivatives as cyclin-dependent kinase 2 inhibitors NIKANG THERAPEUTICS, INC. (US) 2025-06-17 US disclosed
WO-2025122545-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS INCYTE CORPORATION (US) 2025-06-12 WO disclosed
US-20250179083-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS INCYTE CORPORATION 2025-06-05 US disclosed
US-8940741-B2 Inhibitors of bruton's tyrosine kinase HOFFMANN-LA ROCHE INC. (US) 2015-01-27 US disclosed
EP-2603500-B1 INHIBITORS OF BRUTON'S TYROSINE KINASE HOFFMANN LA ROCHE (CH) 2014-11-19 EP disclosed
US-20140309213-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL MERCK SHARP & DOHME LLC 2014-10-16 US disclosed
US-20140296206-A1 COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT BLUEPRINT MEDICINES CORPORATION (US) 2014-10-02 US disclosed
US-20140206663-A1 TRIAZINONE COMPOUNDS WUXI APPTECH (SHANGHAI) CO., LTD. (CN) 2014-07-24 US disclosed
US-20140206663-A1 TRIAZINONE COMPOUNDS WUXI APPTECH (SHANGHAI) CO., LTD. (CN) 2014-07-24 US disclosed
WO-2014089904-A1 TRIAZINONE COMPOUNDS ABBVIE INC. (US) 2014-06-19 WO disclosed
US-20130178461-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE HOFFMANN-LA ROCHE INC. (US) 2013-07-11 US disclosed
US-8481540-B2 Inhibitors of bruton's tyrosine kinase HOFFMANN-LA ROCHE INC. (US) 2013-07-09 US disclosed
US-20120040949-A1 Inhibitors of Bruton's Tyrosine Kinase BERTHEL STEVEN JOSEPH (US) 2012-02-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12545659-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK4 NR1H2 319/4885CHRNB2 2504/4885CHRNA3 1977/4885
US-20140296206-A1 COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT KIT, APC, CKMT1A; CKMT1B NR1H2 1246/4885CHRNB2 855/4885CHRNA3 1700/4885
US-20140206663-A1 TRIAZINONE COMPOUNDS THPO, IL5, CYP11B2 NR1H2 211/4885CHRNB2 4745/4885CHRNA3 4629/4885
US-12331026-B2 Sulfonamido derivatives as cyclin-dependent kinase 2 inhibitors CDK2, CCNK, CCNI NR1H2 3359/4885CHRNB2 4818/4885CHRNA3 4883/4885
US-20250276964-A1 Benzisoxazole Derivatives and Uses thereof HBZ, ZFX, WIZ NR1H2 1557/4885CHRNB2 2282/4885CHRNA3 1475/4885
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK4 NR1H2 69/4885CHRNB2 1229/4885CHRNA3 798/4885
US-20250179083-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS DGKA, DGKI, DGKG NR1H2 1712/4885CHRNB2 4693/4885CHRNA3 4388/4885
US-20140309213-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL KCNJ2, KCNJ11, KCNJ1 NR1H2 1695/4885CHRNB2 1398/4885CHRNA3 1691/4885
US-12371426-B2 Pyridazine derivatives as SMARCA2/4 degraders SMARCC1, SMARCC2, SMARCA2 NR1H2 2054/4885CHRNB2 1296/4885CHRNA3 2264/4885
US-20120040949-A1 Inhibitors of Bruton's Tyrosine Kinase BTK, SYK, LYN NR1H2 2358/4885CHRNB2 4010/4885CHRNA3 4195/4885
US-20260137676-A1 PIPERAZINE SUBSTITUTED PHENOL DERIVATIVE AND USE THEREOF CNR1, SIGMAR1, CBR1 NR1H2 34/4885CHRNB2 615/4885CHRNA3 204/4885
US-20130178461-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, SYK, LYN NR1H2 2358/4885CHRNB2 4010/4885CHRNA3 4195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.