Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.88 |
| ▸ | TPH2 | Q8IWU9 | 20/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18036506 | 0.94 | TPH2 (1.00) | TPH1TPH2 | |
| SCHEMBL18036509 | 0.87 | TPH2 (1.00) | TPH1TPH2 | |
| SCHEMBL18036513 | 0.87 | TPH1 (0.76) | TPH1TPH2 | |
| SCHEMBL18036477 | 0.86 | TPH2 (0.85) | TPH1TPH2 | |
| SCHEMBL18036479 | 0.84 | TPH2 (0.88) | TPH1TPH2 | |
| SCHEMBL18036527 | 0.83 | TPH2 (0.90) | TPH1TPH2 | |
| SCHEMBL18036487 | 0.83 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL18036524 | 0.83 | TPH2 (1.00) | TPH1TPH2 | |
| SCHEMBL18053119 | 0.83 | TPH2 (1.00) | TPH1TPH2 | |
| SCHEMBL18036511 | 0.83 | TPH2 (1.00) | TPH1TPH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262044-A1 | XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016135199-A1 | XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2016-09-01 | — | — | WO | disclosed |