Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 7/20 | 0.42 |
| ▸ | TUBB | P07437 | 7/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415320 | 0.75 | ALDH1A1 (0.51) | KDM4E | |
| SCHEMBL23146824 | 0.74 | TUBB4A (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29812441 | 0.74 | TUBB4A (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL11937846 | 0.68 | — | — | |
| SCHEMBL30367326 | 0.67 | TYK2 (0.47) | DHODHKDM4E | |
| SCHEMBL25208803 | 0.67 | TYK2 (0.47) | DHODHKDM4E | |
| SCHEMBL29812337 | 0.66 | TUBB4A (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL15167466 | 0.65 | MAPK1 (0.43) | KDM4EKDM5AKDM4CKDM5B | |
| SCHEMBL31585949 | 0.65 | FOLH1 (0.57) | CA1CA2FABP3FABP4DHODH | |
| SCHEMBL5024503 | 0.65 | LTB4R2 (0.51) | CA1CA2FABP3FABP4DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2410858-B1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME (US) | 2016-09-07 | — | — | EP | disclosed |