Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22702218 | 0.78 | KDM4A (0.47) | HDAC1KDM4ANAMPTCA1CYP2D6 | |
| SCHEMBL16020324 | 0.75 | GRM2 (0.43) | HDAC1KDM4ANAMPTCYP2D6GLS | |
| SCHEMBL18057687 | 0.75 | CYP3A4 (0.41) | NAMPTCA1IDO1CTSKNR1H2 | |
| SCHEMBL3838871 | 0.74 | CA12 (0.63) | HDAC1KDM4ANAMPTCA12CA1 | |
| SCHEMBL8279661 | 0.73 | POLB (0.53) | KDM4ANAMPTCA12CA1CA7 | |
| SCHEMBL16405266 | 0.73 | SLC7A5 (0.49) | HDAC1KDM4ANAMPTGLSL3MBTL1 | |
| SCHEMBL31143012 | 0.72 | KDM4A (0.42) | HDAC1KDM4ABRD9BAZ2BBAZ2A | |
| SCHEMBL18041414 | 0.72 | KDM4A (0.42) | HDAC1KDM4ABRD9BAZ2BBAZ2A | |
| SCHEMBL12133585 | 0.72 | HDAC1 (0.58) | HDAC1KDM4ANAMPTCA12CA1 | |
| SCHEMBL18041420 | 0.72 | KDM4A (0.42) | HDAC1KDM4ANAMPTCA1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107295798-B | Benzazepine dicarboxamide compound | 豪夫迈·罗氏有限公司 | 2020-10-30 | — | — | CN | disclosed |
| EP-3265458-B1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-12-19 | — | — | EP | disclosed |
| EP-3265458-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2018-01-10 | — | — | EP | disclosed |
| US-9822065-B1 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-11-21 | — | — | US | disclosed |
| US-9822065-B1 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-11-21 | — | — | US | disclosed |
| US-9597333-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-9597333-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-9475775-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475775-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-10-25 | — | — | US | disclosed |
| WO-2016142250-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016142250-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | TLR1, TLR4, TLR5 | HDAC1 179/4885KDM4A 353/4885BRD9 367/4885 |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | TLR1, TLR4, TLR5 | HDAC1 179/4885KDM4A 353/4885BRD9 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.