Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CHAT | P28329 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL1804188 | 1.00 | ALDH1A1 (0.68) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| SCHEMBL13964870 | 0.98 | ALDH1A1 (0.70) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| SCHEMBL18383563 | 0.88 | ALDH1A1 (0.85) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| SCHEMBL18383564 | 0.84 | ALDH1A1 (0.79) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| Iodide SCHEMBL31042224 | 0.84 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| Iodide SCHEMBL1804717 | 0.83 | ALDH1A1 (0.96) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| Iodide SCHEMBL1804720 | 0.83 | ALDH1A1 (0.96) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| SCHEMBL9770819 | 0.82 | CHAT (0.61) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| SCHEMBL12125135 | 0.82 | CHAT (0.61) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E | |
| SCHEMBL13615223 | 0.79 | ALDH1A1 (0.72) | ALDH1A1MAPTSMN1; SMN2GLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120294808-A1 | Fluorescent Analogs of Neurotransmitters, Compositions Containing the Same and Methods of Using the Same | UNIVERSITY OF MIAMI (US) | 2012-11-22 | — | — | US | disclosed |
| WO-2011057229-A2 | FLUORESCENT ANALOGS OF NEUROTRANSMITTERS, COMPOSITIONS CONTAINING THE SAME AND METHODS OF USING THE SAME | UNIVERSITY OF MIAMI (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120294808-A1 | Fluorescent Analogs of Neurotransmitters, Compositions Containing the Same and Methods of Using the Same | HRH3, CHRNA4, HRH4 | ACHE 1250/4885ALDH1A1 1735/4885MAPT 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.