Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 4/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041673 | 0.88 | MAPK14 (0.90) | MAPK14CYP3A4MAPT | |
| SCHEMBL18041853 | 0.88 | MAPK14 (1.00) | MAPK14IDO1 | |
| SCHEMBL18041513 | 0.83 | MAPK14 (0.69) | MAPK14CYP3A4KDM4EMAPT | |
| SCHEMBL5836210 | 0.81 | MAPK14 (0.78) | MAPK14MAPTIDO1 | |
| SCHEMBL18041632 | 0.81 | MAPK14 (0.78) | MAPK14MAPTIDO1 | |
| SCHEMBL18041709 | 0.81 | MAPK14 (0.91) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL18041508 | 0.77 | MAPK14 (0.86) | MAPK14IDO1 | |
| SCHEMBL18041834 | 0.77 | MAPK14 (0.80) | MAPK14MAPTIDO1 | |
| SCHEMBL18041875 | 0.77 | MAPK14 (0.80) | MAPK14CYP3A4IDO1 | |
| SCHEMBL18041868 | 0.77 | MAPK14 (0.86) | MAPK14IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352360-B2 | TGF-beta inhibitors | Rigel Pharmaceuticals, hic. (US) | 2022-06-07 | — | — | US | disclosed |
| CN-107406412-B | TGF-beta inhibitors | 里格尔药品股份有限公司 | 2021-07-16 | — | — | CN | disclosed |
| US-20200031832-A1 | TGF-Beta Inhibitors | MIDCAP FINANCIAL TRUST | 2020-01-30 | — | — | US | disclosed |
| US-10287295-B2 | TGF-β inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2019-05-14 | — | — | US | disclosed |
| US-20180127426-A1 | TGF-Beta Inhibitors | MIDCAP FINANCIAL TRUST | 2018-05-10 | — | — | US | disclosed |
| US-9884868-B2 | TGF-beta inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20160257690-A1 | TGF-Beta Inhibitors | MIDCAP FINANCIAL TRUST | 2016-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352360-B2 | TGF-beta inhibitors | TGFBR1, TGFBR2, TGFB1 | MAPK14 2266/4885CYP3A4 3457/4885KDM4E 1524/4885 |
| US-20200031832-A1 | TGF-Beta Inhibitors | TGFBR1, TGFBR2, TGFB1 | MAPK14 2266/4885CYP3A4 3457/4885KDM4E 1524/4885 |
| US-20180127426-A1 | TGF-Beta Inhibitors | TGFBR1, TGFBR2, TGFB1 | MAPK14 2266/4885CYP3A4 3457/4885KDM4E 1524/4885 |
| US-10287295-B2 | TGF-β inhibitors | TGFBR1, TGFBR2, TGFB1 | MAPK14 2085/4885CYP3A4 3442/4885KDM4E 1317/4885 |
| US-20160257690-A1 | TGF-Beta Inhibitors | TGFBR1, TGFBR2, TGFB1 | MAPK14 2266/4885CYP3A4 3457/4885KDM4E 1524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.