Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 11/20 | 0.40 |
| ▸ | NPY1R | P25929 | 6/20 | 0.40 |
| ▸ | NPY2R | P49146 | 4/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL18042256 | 0.97 | NPY4R (0.40) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Tyrosine SCHEMBL18042253 | 0.96 | NPY4R (0.40) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Tyrosine SCHEMBL18042254 | 0.95 | NPY4R (0.44) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Tyrosine SCHEMBL29246488 | 0.91 | NPY4R (0.40) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Arginine SCHEMBL17889143 | 0.89 | GSR (0.34) | NPY4RNPY1R | |
| Arginine SCHEMBL15941088 | 0.89 | GSR (0.34) | NPY4RNPY1R | |
| Tyrosine SCHEMBL28716900 | 0.89 | NPY4R (0.39) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Arginine SCHEMBL18042251 | 0.86 | TUBB4A (0.35) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Tyrosine SCHEMBL28040626 | 0.86 | NPY4R (0.41) | NPY4RNPY1RNPY2RNPY5RKDM1A | |
| Tyrosine SCHEMBL28537510 | 0.86 | NPY4R (0.39) | NPY4RNPY1RNPY2RNPY5RKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372504-A1 | PHOSPHORYLCHOLINE-TUFTSIN CONJUGATE FOR TREATING OCULAR INFLAMMATION | Tarsier Pharma Ltd (IL) | 2023-11-23 | — | — | US | disclosed |
| US-20230338461-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2023-10-26 | — | — | US | disclosed |
| US-11696935-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2023-07-11 | — | — | US | disclosed |
| US-20210161992-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2021-06-03 | — | — | US | disclosed |
| US-20210069284-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2021-03-11 | — | — | US | disclosed |
| US-10881707-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2021-01-05 | — | — | US | disclosed |
| US-10842844-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2020-11-24 | — | — | US | disclosed |
| US-20200345857-A1 | PHOSPHORYLCHOLINE-TUFTSIN CONJUGATE FOR TREATING OCULAR INFLAMMATION | TARSIER PHARMA LTD. (IL) | 2020-11-05 | — | — | US | disclosed |
| US-20180353566-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2018-12-13 | — | — | US | disclosed |
| US-20180280466-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2018-10-04 | — | — | US | disclosed |
| US-20160256516-A1 | Phosphorylcholine Conjugates and Uses Thereof | TPCERA LTD. (IL) | 2016-09-08 | — | — | US | disclosed |