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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL18042256

C[C@@H](OC(=O)[C@@H](N)CCCCN)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 13/20 0.40
▸ NPY1R P25929 7/20 0.40
▸ NPY2R P49146 5/20 0.39
▸ NPY5R Q15761 5/20 0.39
▸ KDM1A O60341 3/20 0.36
▸ MAOB P27338 1/20 0.36
▸ KDM5A P29375 1/20 0.36
▸ KDM1B Q8NB78 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL18042253 0.97 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RKDM1A
Tyrosine SCHEMBL18042245 0.97 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RKDM1A
Tyrosine SCHEMBL18042254 0.95 NPY4R (0.44) NPY4RNPY1RNPY2RNPY5RKDM1A
Arginine SCHEMBL15941088 0.89 GSR (0.34) NPY4RNPY1R
Arginine SCHEMBL17889143 0.89 GSR (0.34) NPY4RNPY1R
Tyrosine SCHEMBL29246488 0.88 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RKDM1A
Arginine SCHEMBL8613184 0.87 KDM1A (0.33) NPY4RNPY1RNPY2RNPY5RKDM1A
Arginine SCHEMBL18042259 0.86 TUBB4A (0.33) —
Tyrosine SCHEMBL28916433 0.86 NPY4R (0.43) NPY4RNPY1RNPY2RNPY5R
Arginine SCHEMBL15941501 0.85 PRCP (0.34) NPY4RNPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230338461-A1 PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF TPCERA LTD. (IL) 2023-10-26 — — US disclosed
US-11696935-B2 Phosphorylcholine conjugates and uses thereof TPCERA LTD. (IL) 2023-07-11 — — US disclosed
US-20210161992-A1 PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF TPCERA LTD. (IL) 2021-06-03 — — US disclosed
US-20210069284-A1 PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF TPCERA LTD. (IL) 2021-03-11 — — US disclosed
US-10881707-B2 Phosphorylcholine conjugates and uses thereof TPCERA LTD. (IL) 2021-01-05 — — US disclosed
US-10842844-B2 Phosphorylcholine conjugates and uses thereof TPCERA LTD. (IL) 2020-11-24 — — US disclosed
US-20180353566-A1 PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF TPCERA LTD. (IL) 2018-12-13 — — US disclosed
US-20180280466-A1 PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF TPCERA LTD. (IL) 2018-10-04 — — US disclosed
US-20160256516-A1 Phosphorylcholine Conjugates and Uses Thereof TPCERA LTD. (IL) 2016-09-08 — — US disclosed