Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.33 |
| ▸ | TUBB | P07437 | 2/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL18042252 | 0.95 | TUBB4A (0.33) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL18042250 | 0.94 | TUBB4A (0.32) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL18042246 | 0.93 | TUBB4A (0.33) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL18042249 | 0.92 | C5AR1 (0.33) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL18042259 | 0.89 | TUBB4A (0.33) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL18042251 | 0.88 | TUBB4A (0.35) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL18042243 | 0.87 | MC4R (0.33) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL27090217 | 0.86 | TUBB4A (0.36) | C5AR1TUBB4ATUBBTUBA3CTUBA1B | |
| Histidine SCHEMBL3750030 | 0.84 | KLK7 (0.30) | — | |
| Histidine SCHEMBL9294075 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230338461-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2023-10-26 | — | — | US | disclosed |
| US-11696935-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2023-07-11 | — | — | US | disclosed |
| US-20210161992-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2021-06-03 | — | — | US | disclosed |
| US-20210069284-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2021-03-11 | — | — | US | disclosed |
| US-10881707-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2021-01-05 | — | — | US | disclosed |
| US-10842844-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2020-11-24 | — | — | US | disclosed |
| US-20180353566-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2018-12-13 | — | — | US | disclosed |
| US-20180280466-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2018-10-04 | — | — | US | disclosed |
| WO-2017094014-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | TPCERA LTD. (IL) | 2017-06-08 | — | — | WO | disclosed |
| US-20160256516-A1 | Phosphorylcholine Conjugates and Uses Thereof | TPCERA LTD. (IL) | 2016-09-08 | — | — | US | disclosed |