Histidine

Histidine

SCHEMBL3750030

C[C@@H](OC(=O)[C@@H](N)CCCNC(=N)N)[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)OC(=O)[C@@H]1CCCN1.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.31

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KLK7 P49862 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL2513267 0.87
Arginine SCHEMBL18042250 0.86 TUBB4A (0.32)
Arginine SCHEMBL18042252 0.86 TUBB4A (0.33)
Arginine SCHEMBL18042246 0.85 TUBB4A (0.33)
Arginine SCHEMBL18042247 0.84 C5AR1 (0.33)
Arginine SCHEMBL18042259 0.84 TUBB4A (0.33)
Arginine SCHEMBL18042249 0.84 C5AR1 (0.33)
Arginine SCHEMBL18042251 0.84 TUBB4A (0.35)
Histidine SCHEMBL7765125 0.83
Arginine SCHEMBL18042243 0.83 MC4R (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2101804-B1 PRO-ANGIOGENIC PEPTIDES SUSAVION BIOSCIENCES INC (US) 2016-02-17 EP disclosed
US-7838497-B2 Pro-angiogenic peptides SUSAVION BIOSCIENCES, INC. (US) 2010-11-23 US disclosed
EP-2101804-A2 PRO-ANGIOGENIC PEPTIDES Susavion Biosciences, Inc. (US) 2009-09-23 EP disclosed
US-20080233081-A1 PRO-ANGIOGENIC PEPTIDES SUSAVION BIOSCIENCES, INC. (US) 2008-09-25 US disclosed
WO-2008076815-A2 PRO-ANGIOGENIC PEPTIDES SUSAVION BIOSCIENCES, INC. (US) 2008-06-26 WO disclosed