Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.46 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18070981 | 1.00 | EGLN1 (0.50) | EGLN1KDRRETMAP3K20RIPK3 | |
| SCHEMBL18049010 | 0.89 | EGLN1 (0.52) | EGLN1KDRVNN1MEN1MAPT | |
| SCHEMBL18070983 | 0.89 | EGLN1 (0.52) | EGLN1KDRVNN1MEN1MAPT | |
| SCHEMBL18049826 | 0.87 | EGLN1 (0.51) | EGLN1KDRRETMAP3K20RIPK3 | |
| SCHEMBL18070937 | 0.85 | VNN1 (0.45) | EGLN1RETVNN1KMT2AGAA | |
| SCHEMBL18049004 | 0.85 | VNN1 (0.45) | EGLN1RETVNN1KMT2AGAA | |
| SCHEMBL18070979 | 0.84 | KDR (0.53) | KDRVNN1MEN1MAPTKMT2A | |
| SCHEMBL18048947 | 0.84 | KDR (0.53) | KDRVNN1MEN1MAPTKMT2A | |
| SCHEMBL18070984 | 0.84 | EGLN1 (0.48) | EGLN1KDRRETMAP3K20RIPK3 | |
| SCHEMBL18070989 | 0.84 | EGLN1 (0.48) | EGLN1KDRRETMAP3K20RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | claimed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |