Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.60 |
| ▸ | FLT1 | P17948 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | VNN1 | O95497 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.48 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.48 |
| ▸ | ASPH | Q12797 | 1/20 | 0.48 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18049825 | 0.90 | KDR (0.64) | KDRFLT1MAPTCTNNB1TCF7L2 | |
| SCHEMBL18048995 | 0.87 | KDR (0.64) | KDRFLT1MAPT | |
| SCHEMBL18049009 | 0.87 | PDPK1 (0.47) | KDRFLT1MAPTVNN1PDPK1 | |
| SCHEMBL18048964 | 0.86 | KDR (0.51) | KDRFLT1VNN1PDPK1 | |
| SCHEMBL18048981 | 0.86 | KDR (0.56) | KDRFLT1MAPTVNN1PDPK1 | |
| SCHEMBL18048972 | 0.86 | KDR (0.61) | KDRFLT1MAPTPDPK1CTNNB1 | |
| Hydrochloric Acid SCHEMBL18049005 | 0.86 | PDPK1 (0.46) | KDRFLT1MAPTVNN1PDPK1 | |
| SCHEMBL18048998 | 0.85 | ALDH1A1 (0.57) | PDPK1CTNNB1TCF7L2 | |
| SCHEMBL18049787 | 0.85 | GRM4 (0.52) | KDRFLT1VNN1PDPK1PTK2 | |
| SCHEMBL18049823 | 0.85 | KDR (0.48) | KDRFLT1VNN1PDPK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | claimed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |