Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.64 |
| ▸ | FLT1 | P17948 | 5/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PPIA | P62937 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048985 | 0.90 | KDR (0.60) | KDRFLT1CTNNB1TCF7L2MAPT | |
| SCHEMBL15528901 | 0.85 | KDR (0.87) | KDRMAPTPPIAMEN1ALDH1A1 | |
| SCHEMBL18049033 | 0.82 | MAPT (0.57) | KDRFLT1MAPTNPC1RAB9A | |
| SCHEMBL18048995 | 0.79 | KDR (0.64) | KDRFLT1MAPTMEN1ALDH1A1 | |
| SCHEMBL18048946 | 0.79 | MAPT (0.60) | KDRFLT1MAPTNPC1RAB9A | |
| SCHEMBL427743 | 0.78 | KDR (1.00) | KDRFLT1 | |
| SCHEMBL26921256 | 0.78 | ASPH (0.55) | KDRFLT1ASPHKDM8 | |
| SCHEMBL3915690 | 0.77 | MAPT (0.66) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL6103635 | 0.77 | KDR (0.80) | KDRFLT1MAPTMEN1ALDH1A1 | |
| SCHEMBL18049009 | 0.76 | PDPK1 (0.47) | KDRFLT1CTNNB1TCF7L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |