Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18070874 | 1.00 | KDR (0.47) | KDRPRKCQPRKCDRXFP1MEN1 | |
| SCHEMBL18070993 | 0.89 | KDR (0.48) | KDRRXFP1MEN1ALDH1A1LMNA | |
| SCHEMBL18049023 | 0.86 | KDR (0.46) | KDRRXFP1MEN1ALDH1A1LMNA | |
| SCHEMBL18070901 | 0.86 | KDR (0.46) | KDRRXFP1MEN1ALDH1A1LMNA | |
| SCHEMBL18070900 | 0.86 | KDR (0.46) | KDRRXFP1MEN1ALDH1A1LMNA | |
| SCHEMBL18070873 | 0.86 | KDR (0.44) | KDRRXFP1MEN1ALDH1A1LMNA | |
| SCHEMBL18070979 | 0.83 | KDR (0.53) | KDRRXFP1MEN1ALDH1A1LMNA | |
| SCHEMBL18048947 | 0.83 | KDR (0.53) | KDRRXFP1MEN1ALDH1A1LMNA | |
| SCHEMBL18048951 | 0.82 | EGLN1 (0.50) | KDRMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL18048948 | 0.82 | KDR (0.63) | KDRRXFP1MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | claimed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |