Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | CA7 | P43166 | 2/20 | 0.63 |
| ▸ | CTSK | P43235 | 12/20 | 0.57 |
| ▸ | CTSS | P25774 | 12/20 | 0.57 |
| ▸ | CTSL | P07711 | 4/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21085559 | 1.00 | CA1 (0.63) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL2506424 | 0.84 | CA1 (0.59) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL4118840 | 0.83 | CTSK (0.56) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL86153 | 0.83 | CTSK (0.56) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL86185 | 0.83 | CTSK (0.56) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL1370051 | 0.81 | CTSK (0.55) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL1414602 | 0.79 | CA1 (0.71) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL1809665 | 0.79 | CA1 (0.71) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL1134642 | 0.79 | CA1 (0.71) | CA1CA2CA7CTSKCTSS | |
| SCHEMBL38665117 | 0.79 | CA1 (0.71) | CA1CA2CA7CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3261443-B1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIV RICE WILLIAM M (US) | 2021-04-28 | — | — | EP | disclosed |
| US-10808007-B2 | Desacetoxytubulysin H and analogs thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-05-10 | — | — | US | disclosed |
| WO-2016138288-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | REN, MAN2B2, UTS2R | CA1 4446/4885CA2 3753/4885CA7 3276/4885 |
| US-10808007-B2 | Desacetoxytubulysin H and analogs thereof | REN, MAN2B2, UTS2R | CA1 4446/4885CA2 3753/4885CA7 3276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.