Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038300 | 0.83 | EGFR (0.42) | ROCK2NPC1ALDH1A1MAPTHPGD | |
| SCHEMBL14514349 | 0.77 | ROCK2 (0.63) | ROCK2NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5817971 | 0.75 | ROCK2 (0.64) | ROCK2ROCK1CYP3A4 | |
| SCHEMBL312320 | 0.74 | ROCK2 (0.68) | ROCK2NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL11889768 | 0.72 | NPC1 (0.57) | TRPV1ROCK2NPC1MAPTRAB9A | |
| SCHEMBL625972 | 0.70 | ROCK2 (0.66) | POLBROCK2NPC1RAB9AROCK1 | |
| SCHEMBL16600091 | 0.70 | POLB (0.52) | POLBTRPV1ROCK2NPC1ALDH1A1 | |
| SCHEMBL6881915 | 0.70 | PIK3CD (0.54) | POLBROCK2PIK3CDMAPTCYP3A4 | |
| SCHEMBL6881911 | 0.70 | PIK3CD (0.54) | POLBROCK2PIK3CDMAPTCYP3A4 | |
| SCHEMBL23167233 | 0.70 | ROCK2 (0.46) | POLBTRPV1ROCK2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016138335-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | LYCERA CORPORATION (US) | 2016-09-01 | — | — | WO | disclosed |