Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14514349 | 0.94 | ROCK2 (0.63) | ROCK2ROCK1CYP3A4CCR2 | |
| SCHEMBL312320 | 0.88 | ROCK2 (0.68) | ROCK2ROCK1CYP3A4CCR2 | |
| SCHEMBL314219 | 0.84 | USP30 (0.50) | ROCK2 | |
| SCHEMBL5823981 | 0.84 | ROCK2 (0.61) | ROCK2ROCK1CYP3A4CCR2 | |
| SCHEMBL5823982 | 0.81 | ROCK2 (0.63) | ROCK2ROCK1CCR2 | |
| SCHEMBL5407903 | 0.80 | PIK3CD (0.56) | ROCK2ROCK1CCR2 | |
| SCHEMBL18937875 | 0.80 | ALDH1A1 (0.57) | — | |
| SCHEMBL24596918 | 0.79 | FPR2 (0.64) | — | |
| SCHEMBL13434252 | 0.79 | ALDH1A1 (0.58) | — | |
| SCHEMBL24596980 | 0.79 | FPR2 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| WO-2006135383-A2 | INDAZOLES | MYRIAD GENETICS, INC. (US) | 2006-12-21 | — | — | WO | disclosed |