Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 5/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20513056 | 0.84 | TLR7 (0.47) | TLR7 | |
| SCHEMBL4059711 | 0.72 | MGMT (0.47) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL18056913 | 0.71 | CDK1 (0.42) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL4062331 | 0.70 | KDR (0.39) | CYP1A2MAPK1TSHRPDPK1KDR | |
| SCHEMBL598441 | 0.70 | CYP2D6 (0.43) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL21462266 | 0.66 | TLR7 (0.42) | CYP3A4CYP2D6TLR7 | |
| SCHEMBL9375291 | 0.66 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28081599 | 0.66 | CYP2D6 (0.39) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL26174401 | 0.65 | CDK1 (0.48) | CDK1CCNB1CDK2CCNA2CCNA1 | |
| SCHEMBL899058 | 0.64 | NR5A1 (0.43) | CDK1CCNB1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170014415-A1 | THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF | UNIV MARYLAND (US) | 2017-01-19 | — | — | US | disclosed |
| US-20160257696-A1 | THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY | 2016-09-08 | — | — | US | disclosed |
| US-9434742-B1 | Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2016-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160257696-A1 | THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF | TYMP, MKI67, TYMS | CDK1 251/4885CCNB1 276/4885CDK2 93/4885 |
| US-20170014415-A1 | THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF | TYMP, MKI67, TYMS | CDK1 251/4885CCNB1 276/4885CDK2 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.