Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4077489 | 0.86 | POLB (0.63) | POLBLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL2913521 | 0.84 | USP2 (0.65) | POLBLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL5725656 | 0.82 | ATM (0.58) | POLBLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12793245 | 0.82 | POLB (0.88) | POLBLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL12793258 | 0.77 | POLB (1.00) | POLBLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL15544302 | 0.77 | TSHR (0.41) | POLBLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL6117914 | 0.75 | KDM4E (0.62) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL12793270 | 0.75 | POLB (0.96) | POLBLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL28072234 | 0.75 | POLB (0.76) | POLBLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL8871272 | 0.75 | POLB (0.76) | POLBLMNASMN1; SMN2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497371-B2 | Pipemidic acid derivative autotaxin inhibitors | UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120100592-A1 | PIPEMIDIC ACID DERIVATIVE AUTOTAXIN INHIBITORS | THE UNIVERSITY OF MEMPHIS | 2012-04-26 | — | — | US | disclosed |
| WO-2011053597-A1 | PIPEMIDIC ACID DERIVATIVE AUTOTAXIN INHIBITORS | THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION (US) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100592-A1 | PIPEMIDIC ACID DERIVATIVE AUTOTAXIN INHIBITORS | ENPP2, PLA2G6, PLA2G10 | POLB 2710/4885LMNA 1624/4885SMN1; SMN2 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.