Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.35 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46807 | 0.89 | SLC34A2 (0.41) | KDM4EBRAFDDR2HRH4SMYD2 | |
| SCHEMBL15432568 | 0.87 | SLC34A2 (0.45) | KDM4EBRAFHRH4SMYD2ROCK2 | |
| SCHEMBL46676 | 0.83 | SLC34A2 (0.43) | KDM4EBRAFDDR2HRH4SMYD2 | |
| SCHEMBL19579955 | 0.83 | SLC34A2 (0.46) | KDM4EBRAFHRH4SMYD2ROCK2 | |
| SCHEMBL40112 | 0.81 | SLC34A2 (0.48) | KDM4EBRAFHRH4SMYD2ROCK2 | |
| SCHEMBL40133 | 0.81 | SLC34A2 (0.41) | KDM4EBRAFDDR2HRH4SMYD2 | |
| SCHEMBL46466 | 0.81 | SLC34A2 (0.41) | KDM4EBRAFDDR2HRH4SMYD2 | |
| SCHEMBL16804643 | 0.81 | BRAF (0.43) | KDM4EBRAFHRH4ROCK2SLC34A2 | |
| SCHEMBL40137 | 0.81 | CHRM3 (0.43) | KDM4EBRAFDDR2HRH4SMYD2 | |
| SCHEMBL18059165 | 0.79 | CHRM3 (0.45) | KDM4EBRAFHRH4SMYD2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |