Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46675 | 0.86 | DRD4 (0.43) | MRGPRX4DRD4JMJD6CASRALDH1A1 | |
| SCHEMBL2731240 | 0.86 | CASR (0.44) | MRGPRX4DRD4JMJD6CASRALDH1A1 | |
| SCHEMBL46674 | 0.79 | KDM5A (0.43) | DRD4CASRSMYD2KDM1AHDAC1 | |
| SCHEMBL18059160 | 0.78 | BRAF (0.40) | SMYD2KDM1AHDAC1 | |
| SCHEMBL18059165 | 0.77 | CHRM3 (0.45) | SMYD2 | |
| SCHEMBL19595482 | 0.77 | RAF1 (0.42) | DRD4ALDH1A1 | |
| SCHEMBL46836 | 0.77 | CNR2 (0.42) | DRD4ALDH1A1SMYD2KDM1AHDAC1 | |
| SCHEMBL40023 | 0.76 | ALDH1A1 (0.56) | MRGPRX4DRD4CASRALDH1A1PRKDC | |
| SCHEMBL18484260 | 0.75 | MAPK14 (0.41) | MRGPRX4DRD4ALDH1A1 | |
| SCHEMBL6001362 | 0.75 | SLC34A2 (0.48) | KDM1AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |