Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 6/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39781 | 0.91 | SLC34A2 (0.53) | SLC34A2KDM4EHRH4BRAFROCK2 | |
| SCHEMBL39966 | 0.86 | SLC34A2 (0.48) | SLC34A2KDM4EHRH4BRAFROCK2 | |
| SCHEMBL46804 | 0.84 | SLC34A2 (0.61) | SLC34A2KDM4EHRH4BRAFROCK2 | |
| SCHEMBL18059149 | 0.82 | ROCK2 (0.44) | SLC34A2KDM4EHRH4BRAFROCK2 | |
| SCHEMBL15432720 | 0.80 | SLC34A2 (0.54) | SLC34A2KDM4EBRAFROCK2ROCK1 | |
| SCHEMBL6001195 | 0.79 | SLC34A2 (0.56) | SLC34A2KDM4EHRH4BRAFROCK2 | |
| SCHEMBL16355204 | 0.79 | SLC34A2 (0.53) | SLC34A2KDM4EBRAFROCK2ROCK1 | |
| SCHEMBL18059162 | 0.79 | SLC34A2 (0.49) | SLC34A2KDM4EBRAFROCK2ROCK1 | |
| SCHEMBL46969 | 0.78 | SLC34A2 (0.54) | SLC34A2KDM4EBRAFROCK2ROCK1 | |
| SCHEMBL18059177 | 0.77 | SLC34A2 (0.46) | SLC34A2KDM4EHRH4BRAFROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |