Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18821162 | 0.86 | CYP3A4 (0.38) | CYP3A4TSHRALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL16908224 | 0.83 | CYP3A4 (0.35) | CYP3A4TSHRALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL22020507 | 0.83 | HSD17B10 (0.37) | CYP3A4TSHRALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL23638849 | 0.78 | PPARG (0.33) | CYP3A4ALDH1A1KMT2AMEN1 | |
| SCHEMBL14824789 | 0.77 | — | — | |
| SCHEMBL13984459 | 0.77 | ALDH1A1 (0.31) | CYP3A4TSHRALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL19299415 | 0.77 | PTGDR2 (0.36) | TSHRALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL24561700 | 0.75 | IDO1 (0.34) | — | |
| SCHEMBL19299397 | 0.74 | PTGDR2 (0.39) | ALOX15HPGDMAPK1KMT2AMEN1 | |
| SCHEMBL19595730 | 0.74 | MAPT (0.46) | ALDH1A1ALOX15SMN1; SMN2TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |