Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 4/20 | 0.58 |
| ▸ | MMP9 | P14780 | 4/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19557673 | 0.91 | MAPT (0.68) | MAPTTDP1ALOX15PABPC1MMP2 | |
| SCHEMBL18041150 | 0.88 | MAPT (0.65) | MAPTTDP1ALOX15PABPC1MMP2 | |
| SCHEMBL31036056 | 0.88 | ALOX15 (0.71) | MAPTTDP1ALOX15PABPC1MMP2 | |
| SCHEMBL24505575 | 0.86 | MAPT (0.61) | MAPTTDP1ALOX15PABPC1MMP2 | |
| SCHEMBL8271509 | 0.85 | HDAC1 (0.58) | MTNR1AMTNR1BHDAC3HDAC1HDAC2 | |
| SCHEMBL23054983 | 0.81 | ATM (0.59) | MAPTTDP1ALOX15PABPC1HDAC3 | |
| SCHEMBL20242466 | 0.81 | PABPC1 (0.75) | MAPTTDP1ALOX15PABPC1MTNR1A | |
| SCHEMBL22470303 | 0.79 | MAPT (0.49) | MAPTTDP1ALOX15PABPC1ALDH1A1 | |
| SCHEMBL20232415 | 0.78 | HDAC1 (0.69) | MAPTTDP1ALOX15PABPC1HDAC3 | |
| SCHEMBL18059399 | 0.77 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4011454-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION | Shuttle Pharmaceuticals, Inc. (US) | 2022-06-15 | — | — | EP | disclosed |
| US-20220055988-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | SHUTTLE PHARMACEUTICALS INC (US) | 2022-02-24 | — | — | US | disclosed |
| EP-3265073-B1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | SHUTTLE PHARMACEUTICALS INC (US) | 2021-08-18 | — | — | EP | disclosed |
| US-20200317611-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | SHUTTLE PHARMACEUTICALS INC (US) | 2020-10-08 | — | — | US | disclosed |
| US-10745352-B2 | Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof | SHUTTLE PHARMACEUTICALS, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-10730834-B2 | Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof | SHUTTLE PHARMACEUTICALS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20180057456-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | SHUTTLE PHARMACEUTICALS, INC. | 2018-03-01 | — | — | US | disclosed |
| US-20180044292-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | SHUTTLE PHARMACEUTICALS, INC. | 2018-02-15 | — | — | US | disclosed |
| US-9809539-B2 | Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof | SHUTTLE PHARMACEUTICALS, LLC (US) | 2017-11-07 | — | — | US | disclosed |
| US-20160257649-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | SHUTTLE PHARMACEUTICALS, LLC | 2016-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044292-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | ATM, HDAC8, HDAC1 | MAPT 2293/4885TDP1 41/4885ALOX15 4806/4885 |
| US-20180057456-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | ATM, HDAC8, HDAC1 | MAPT 2293/4885TDP1 41/4885ALOX15 4806/4885 |
| US-10745352-B2 | Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof | ATM, HDAC8, HDAC1 | MAPT 2293/4885TDP1 41/4885ALOX15 4806/4885 |
| US-20200317611-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | ATM, HDAC8, HDAC1 | MAPT 2293/4885TDP1 41/4885ALOX15 4806/4885 |
| US-20160257649-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | ATM, HDAC8, HDAC1 | MAPT 2293/4885TDP1 41/4885ALOX15 4806/4885 |
| US-10730834-B2 | Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof | ATM, HDAC8, HDAC1 | MAPT 2293/4885TDP1 41/4885ALOX15 4806/4885 |
| US-20220055988-A1 | DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF | ATM, HDAC8, HDAC1 | MAPT 2293/4885TDP1 41/4885ALOX15 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.