SCHEMBL1805967

SCHEMBL1805967

COC(=O)c1cccc(NC(=O)c2cccc(F)c2)c1F

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.64
POLB P06746 4/20 0.64
TDP1 Q9NUW8 1/20 0.64
LMNA P02545 4/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
CYP1A2 P05177 3/20 0.59
TSHR P16473 2/20 0.59
CYP2D6 P10635 1/20 0.59
CYP2C19 P33261 1/20 0.59
RAB9A P51151 4/20 0.54
NPC1 O15118 3/20 0.54
HTT P42858 1/20 0.54
ALDH1A1 P00352 2/20 0.53
PKM P14618 1/20 0.52
GAA P10253 2/20 0.52
MAPT P10636 1/20 0.52
ROCK2 O75116 1/20 0.52
KDM4E B2RXH2 2/20 0.51
HSD17B10 Q99714 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31187273 0.87 TSHR (0.68) SMN1; SMN2POLBLMNAMEN1KMT2A
SCHEMBL1803117 0.87 TSHR (0.68) SMN1; SMN2POLBLMNAMEN1KMT2A
SCHEMBL1806599 0.86 CYP1A2 (0.79) SMN1; SMN2POLBLMNAMEN1KMT2A
SCHEMBL1804668 0.81 TSHR (0.52) SMN1; SMN2KMT2ACYP1A2TSHRCYP2D6
SCHEMBL21899369 0.78 POLB (0.55) SMN1; SMN2POLBTDP1LMNAMEN1
SCHEMBL13009146 0.78 LMNA (0.51) SMN1; SMN2POLBLMNAKMT2ACYP1A2
SCHEMBL12551319 0.78 TSHR (0.59) SMN1; SMN2POLBLMNAMEN1KMT2A
SCHEMBL1801492 0.78 TSHR (0.59) SMN1; SMN2POLBLMNAMEN1KMT2A
SCHEMBL6434129 0.78 PYGM (0.62) SMN1; SMN2POLBTDP1LMNAMEN1
SCHEMBL14075248 0.77 MEN1 (0.79) SMN1; SMN2POLBTDP1LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2322502-B1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO INC (JP) 2019-09-18 EP disclosed
EP-2322502-B1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO INC (JP) 2019-09-18 EP disclosed
US-9890110-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2018-02-13 US disclosed
US-9890110-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2018-02-13 US disclosed
US-9890110-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2018-02-13 US disclosed
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2016-10-13 US disclosed
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2016-10-13 US disclosed
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2016-10-13 US disclosed
US-9394240-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2016-07-19 US disclosed
US-9394240-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2016-07-19 US disclosed
US-8853440-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2014-10-07 US disclosed
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2014-10-02 US disclosed
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2014-10-02 US disclosed
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2014-10-02 US disclosed
CN-102119144-A Method for producing amide derivative MITSUI CHEMICALS AGRO INC 2011-07-06 CN disclosed
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-09 US disclosed
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-09 US disclosed
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-09 US disclosed
EP-2322502-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE Mitsui Chemicals Agro, Inc. (JP) 2011-05-18 EP disclosed
EP-2322502-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE Mitsui Chemicals Agro, Inc. (JP) 2011-05-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 SMN1; SMN2 3533/4885POLB 4756/4885TDP1 4072/4885
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 SMN1; SMN2 3533/4885POLB 4756/4885TDP1 4072/4885
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 SMN1; SMN2 3533/4885POLB 4756/4885TDP1 4072/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.