Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182490 | 0.83 | APP (0.51) | DGAT1APPPIK3CAKCNH2ABL1 | |
| Hydrochloric Acid SCHEMBL181048 | 0.82 | APP (0.50) | DGAT1APPPIK3CAKCNH2ABL1 | |
| Tert-Butyl Formate SCHEMBL27758111 | 0.74 | DGAT1 (0.45) | DGAT1APPPIK3CAKCNH2PTK2 | |
| SCHEMBL12203214 | 0.74 | DGAT1 (0.69) | DGAT1APPABL1BCRJAK2 | |
| SCHEMBL25145866 | 0.73 | HTR2C (0.57) | APPPIK3CAKCNH2HTR2C | |
| SCHEMBL12129572 | 0.72 | APP (0.70) | APPABL1BCRHTR2C | |
| SCHEMBL29068729 | 0.69 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL29068744 | 0.69 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL30565805 | 0.69 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL901925 | 0.69 | KARS1 (0.67) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402319-A1 | DGAT Inhibitors | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |