Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.59 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.59 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 9/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805553 | 0.87 | BRAF (0.59) | BRAFTNNI3KRAF1EGFRERBB2 | |
| SCHEMBL1809417 | 0.86 | BRAF (0.60) | BRAFTNNI3KRAF1EGFR | |
| SCHEMBL1806890 | 0.84 | BRAF (0.59) | BRAFTNNI3KEGFR | |
| SCHEMBL1804094 | 0.82 | BRAF (0.60) | BRAFTNNI3KRAF1EGFRCD38 | |
| Trifluoroacetic Acid SCHEMBL1807173 | 0.80 | TNNI3K (0.48) | BRAFTNNI3KEGFRHRH3 | |
| SCHEMBL1806419 | 0.78 | BRAF (0.64) | BRAFTNNI3KEGFRHRH3 | |
| SCHEMBL9980396 | 0.75 | TNNI3K (0.44) | BRAFTNNI3KEGFR | |
| SCHEMBL6912449 | 0.74 | TNNI3K (1.00) | BRAFTNNI3K | |
| SCHEMBL2229060 | 0.73 | SLC6A4 (0.46) | TNNI3KEGFR | |
| Hydrochloric Acid SCHEMBL1804731 | 0.72 | BRAF (0.67) | BRAFTNNI3KEGFRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |