Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.60 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806649 | 0.86 | BRAF (0.59) | BRAFTNNI3KEGFRRAF1 | |
| SCHEMBL1805553 | 0.84 | BRAF (0.59) | BRAFTNNI3KNCOA1NCOA3ALDH1A1 | |
| SCHEMBL1806890 | 0.81 | BRAF (0.59) | BRAFTNNI3KEGFRKDR | |
| SCHEMBL1804094 | 0.79 | BRAF (0.60) | BRAFTNNI3KEGFRRAF1 | |
| Trifluoroacetic Acid SCHEMBL1807173 | 0.77 | TNNI3K (0.48) | BRAFTNNI3KEGFRMEN1KMT2A | |
| SCHEMBL6911370 | 0.75 | TNNI3K (1.00) | BRAFTNNI3K | |
| SCHEMBL1806419 | 0.75 | BRAF (0.64) | BRAFTNNI3KEGFRKDR | |
| SCHEMBL9980396 | 0.72 | TNNI3K (0.44) | BRAFTNNI3KEGFR | |
| SCHEMBL4587664 | 0.71 | EGFR (0.70) | BRAFTNNI3KGAANCOA1NCOA3 | |
| SCHEMBL2229060 | 0.70 | SLC6A4 (0.46) | TNNI3KEGFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |