Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806508 | 0.76 | PDE4D (0.49) | PDE4DALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1806224 | 0.76 | PDE4D (0.41) | PDE4DALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1807102 | 0.74 | PDE4D (0.47) | PDE4DALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1805096 | 0.74 | PDE4D (0.47) | PDE4DALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1804789 | 0.74 | PDE4D (0.46) | PDE4DALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1809876 | 0.74 | PDE4D (0.46) | PDE4DNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1806318 | 0.73 | PDE4D (0.50) | PDE4DALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1805132 | 0.71 | NPC1 (0.43) | PDE4DALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1803878 | 0.69 | SLC6A2 (0.40) | PDE4DNPC1RAB9ALMNATHRB | |
| SCHEMBL19209480 | 0.66 | PDE4D (0.59) | PDE4DNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |