Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806508 | 0.88 | PDE4D (0.49) | PDE4DNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1805132 | 0.87 | NPC1 (0.43) | PDE4DNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1804789 | 0.85 | PDE4D (0.46) | PDE4DNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1805096 | 0.82 | PDE4D (0.47) | PDE4DNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1809876 | 0.81 | PDE4D (0.46) | PDE4DNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1806748 | 0.80 | PDE4D (0.47) | PDE4DNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL1806318 | 0.78 | PDE4D (0.50) | PDE4DNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1808962 | 0.77 | TTR (0.37) | KMT2ASMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL1806224 | 0.77 | PDE4D (0.41) | PDE4DNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1808444 | 0.76 | ALDH1A1 (0.36) | KMT2AALDH1A1MEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |