Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13495378 | 0.85 | SMN1; SMN2 (0.52) | PDE4DSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL28346436 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL7409288 | 0.81 | PDE4D (0.48) | PDE4DSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL13615358 | 0.81 | CHEK1 (0.46) | SMN1; SMN2ALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL17279852 | 0.81 | HPGDS (0.60) | SMN1; SMN2ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL6852749 | 0.79 | KDM4E (0.57) | SMN1; SMN2ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL28849703 | 0.78 | KMT2A (0.46) | SMN1; SMN2ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL10172622 | 0.78 | KDM4E (0.56) | SMN1; SMN2ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL21331813 | 0.77 | KDM4E (0.55) | SMN1; SMN2ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL11351745 | 0.77 | ALDH1A1 (0.58) | PDE4DSMN1; SMN2ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| EP-3411375-B1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2020-08-05 | — | — | EP | disclosed |
| US-10189844-B2 | Pyrazole derivatives as phosphoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-01-29 | — | — | US | disclosed |
| EP-3411375-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017134053-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-10 | — | — | WO | disclosed |
| US-20170226109-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | PDE4D 1079/4885SMN1; SMN2 200/4885ALDH1A1 4193/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | PDE4D 1041/4885SMN1; SMN2 263/4885ALDH1A1 4421/4885 |
| US-10189844-B2 | Pyrazole derivatives as phosphoinositide 3-kinases inhibitors | PI4KA, PI4KB, PI4K2B | PDE4D 1315/4885SMN1; SMN2 3039/4885ALDH1A1 3454/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | PDE4D 1079/4885SMN1; SMN2 200/4885ALDH1A1 4193/4885 |
| US-20170226109-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | PI4KA, PI4KB, PI4K2B | PDE4D 1315/4885SMN1; SMN2 3039/4885ALDH1A1 3454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.