Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.51 |
| ▸ | FLT1 | P17948 | 11/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 5/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18049782 | 0.99 | KDR (0.50) | KDRFLT1CTNNB1TCF7L2PTK2 | |
| SCHEMBL18049013 | 0.90 | KDR (0.48) | KDRFLT1CTNNB1TCF7L2PTK2 | |
| SCHEMBL18070995 | 0.87 | KDR (0.62) | KDRFLT1 | |
| SCHEMBL18049787 | 0.86 | GRM4 (0.52) | KDRFLT1PTK2 | |
| SCHEMBL18049823 | 0.86 | KDR (0.48) | KDRFLT1PTK2 | |
| SCHEMBL18049770 | 0.82 | AR (0.51) | KDRFLT1 | |
| SCHEMBL18048984 | 0.82 | KDR (0.45) | KDRFLT1CTNNB1TCF7L2PTK2 | |
| SCHEMBL18048985 | 0.80 | KDR (0.60) | KDRFLT1CTNNB1TCF7L2PTK2 | |
| SCHEMBL18049037 | 0.79 | PRKCI (0.45) | KDRFLT1PTK2 | |
| SCHEMBL18048975 | 0.79 | NAMPT (0.47) | KDRCTNNB1TCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |