Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.32 |
| ▸ | MYLK | Q15746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1808444 | 0.79 | ALDH1A1 (0.36) | TTRKCNN4PDK2P2RX7ALDH1A1 | |
| SCHEMBL1807102 | 0.77 | PDE4D (0.47) | ALDH1A1HSD17B10MEN1MAPTKMT2A | |
| SCHEMBL1805416 | 0.72 | GCGR (0.33) | TTRP2RX7GCGR | |
| SCHEMBL1806508 | 0.69 | PDE4D (0.49) | ALDH1A1HSD17B10MEN1MAPTKMT2A | |
| SCHEMBL1806119 | 0.68 | ALDH1A1 (0.39) | KCNN4GCGRALDH1A1HSD17B10ALOX15 | |
| SCHEMBL1805974 | 0.68 | PRKCQ (0.33) | GCGRALDH1A1NPSR1 | |
| SCHEMBL13248030 | 0.65 | KCNN4 (0.41) | KCNN4PDK2P2RX7ALDH1A1PRKCE | |
| SCHEMBL1808960 | 0.64 | OPRL1 (0.42) | KCNN4HSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1808570 | 0.64 | CYP1A2 (0.39) | P2RX7ALDH1A1HSD17B10ALOX15MAPT | |
| SCHEMBL31214305 | 0.64 | KDM4E (0.37) | GCGRALDH1A1HSD17B10ALOX15PRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |