Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | SRC | P12931 | 5/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 8/20 | 0.61 |
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | KIF5B | P33176 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12227578 | 0.85 | RET (0.70) | EGFRRETKDRFLT1ABCG2 | |
| SCHEMBL5652837 | 0.81 | EGFR (0.87) | EGFRSRCRIPK2NOD1RET | |
| SCHEMBL5649596 | 0.79 | EGFR (0.63) | EGFRSRCRIPK2NOD1RET | |
| SCHEMBL4110679 | 0.79 | RET (0.68) | EGFRRETKDRFLT1ABCG2 | |
| SCHEMBL12510782 | 0.78 | KDR (0.62) | EGFRSRCRETKDRFLT1 | |
| SCHEMBL1807327 | 0.78 | ENPP1 (0.57) | EGFRSRCRIPK2NOD1RET | |
| SCHEMBL18158262 | 0.77 | EGFR (0.69) | EGFRSRCRIPK2RETKDR | |
| SCHEMBL12255622 | 0.76 | SRC (0.58) | EGFRSRCRIPK2RETKDR | |
| SCHEMBL25682990 | 0.76 | KDR (0.78) | EGFRRIPK2RETKDRFLT1 | |
| SCHEMBL8351408 | 0.76 | MAPK1 (0.67) | EGFRSRCRETKDRGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| WO-2005115145-A2 | QUINONE SUBSTITUTED QUINAZOLINE AND QUINOLINE KINASE INHIBITORS | WYETH (US) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | KDR, FLT1, FLT4 | EGFR 439/4885SRC 960/4885RIPK2 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.