Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.46 |
| ▸ | NQO2 | P16083 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27296153 | 0.85 | ALDH1A1 (0.40) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10954823 | 0.83 | CYP19A1 (0.58) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27295494 | 0.81 | ALDH1A1 (0.40) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7031010 | 0.78 | STING1 (0.43) | KDM4EALDH1A1SMN1; SMN2HPGDSTING1 | |
| SCHEMBL2919027 | 0.76 | ALDH1A1 (0.49) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9038259 | 0.72 | CYP19A1 (0.59) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14892531 | 0.71 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2HPGDCA12 | |
| SCHEMBL21642314 | 0.71 | GRIN2D (0.46) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10956862 | 0.71 | ALDH1A1 (0.44) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6395648 | 0.71 | POLB (0.36) | KDM4EALDH1A1HPGDCA12PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3078660-B1 | NOVEL QUINAZOLINE DERIVATIVE | MYCHUNTER THERAPEUTICS INC (JP) | 2022-07-13 | — | — | EP | disclosed |
| US-9682961-B2 | Quinazoline derivative | CARNA BIOSCIENCES, INC. (JP) | 2017-06-20 | — | — | US | disclosed |
| US-9682961-B2 | Quinazoline derivative | CARNA BIOSCIENCES, INC. (JP) | 2017-06-20 | — | — | US | disclosed |
| EP-3078660-A1 | NOVEL QUINAZOLINE DERIVATIVE | Carna Biosciences Inc. (JP) | 2016-10-12 | — | — | EP | disclosed |
| US-20160264555-A1 | NOVEL QUINAZOLINE DERIVATIVE | NATIONAL CANCER CENTER (JP) | 2016-09-15 | — | — | US | disclosed |
| US-20160264555-A1 | NOVEL QUINAZOLINE DERIVATIVE | NATIONAL CANCER CENTER (JP) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264555-A1 | NOVEL QUINAZOLINE DERIVATIVE | WNT1, CTNNB1, CTNND1 | CYP19A1 2605/4885NQO2 341/4885KDM4E 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.