Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CPB1 | P15086 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 3/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20090282 | 0.90 | ALDH1A1 (0.57) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL17852671 | 0.90 | ALDH1A1 (0.57) | ALDH1A1GAATSHRCPB1EPHX1 | |
| Hydrochloric Acid SCHEMBL28380483 | 0.89 | ALDH1A1 (0.56) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL17888176 | 0.88 | ALDH1A1 (0.61) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL17888177 | 0.88 | ALDH1A1 (0.61) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL12987702 | 0.88 | ALDH1A1 (0.57) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL19925393 | 0.86 | ALDH1A1 (0.55) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL16597461 | 0.86 | ALDH1A1 (0.55) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL14169394 | 0.85 | ALDH1A1 (0.54) | ALDH1A1GAATSHRCPB1EPHX1 | |
| SCHEMBL14169235 | 0.85 | ALDH1A1 (0.54) | ALDH1A1GAATSHRCPB1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268367-B1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2022-10-05 | — | — | EP | disclosed |
| US-20180051027-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2018-02-22 | — | — | US | disclosed |
| US-20180051027-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2018-02-22 | — | — | US | disclosed |
| WO-2016144844-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051027-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | IRAK4, IRAK2, IRAK1 | ALDH1A1 1935/4885GAA 1614/4885TSHR 3920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.