Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 8/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PEPD | P12955 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24058760 | 1.00 | REN (0.39) | RENRAB9AACECYP3A4CYP2C9 | |
| SCHEMBL24058544 | 0.87 | ACE (0.37) | RENRAB9AACECYP3A4CYP2C9 | |
| SCHEMBL24058502 | 0.87 | ACE (0.37) | RENRAB9AACECYP3A4CYP2C9 | |
| SCHEMBL21168279 | 0.86 | ACE (0.43) | RENACECYP3A4CYP2C9PKM | |
| SCHEMBL21168328 | 0.86 | ACE (0.43) | RENACECYP3A4CYP2C9PKM | |
| SCHEMBL21168276 | 0.85 | ACE (0.35) | RENACECYP3A4CYP2C9PKM | |
| SCHEMBL21168332 | 0.85 | ACE (0.35) | RENACECYP3A4CYP2C9PKM | |
| SCHEMBL21168380 | 0.85 | FKBP1A (0.35) | RENACECYP3A4CYP2C9PKM | |
| SCHEMBL21168295 | 0.85 | ACE (0.41) | ACE | |
| SCHEMBL21168296 | 0.85 | ACE (0.41) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023645-A1 | 1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | Aurigene Discovery Technologies Limited (IN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3267984-B1 | 1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-11-24 | — | — | EP | disclosed |
| US-20200361880-A1 | 1,2,4-Oxadiazole and Thiadiazole Compounds as Immunomodulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2020-11-19 | — | — | US | disclosed |
| US-10781189-B2 | 1,2,4-Oxadiazole and thiadiazole compounds as immunomodulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2020-09-22 | — | — | US | disclosed |
| US-20180044303-A1 | 1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | AURIGENE ONCOLOGY LIMITED (IN) | 2018-02-15 | — | — | US | disclosed |
| US-20180044303-A1 | 1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | AURIGENE ONCOLOGY LIMITED (IN) | 2018-02-15 | — | — | US | disclosed |
| WO-2016142833-A1 | 1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10781189-B2 | 1,2,4-Oxadiazole and thiadiazole compounds as immunomodulators | PDCD1, PDCD1LG2, CD274 | REN 4666/4885RAB9A 4205/4885ACE 3938/4885 |
| US-20200361880-A1 | 1,2,4-Oxadiazole and Thiadiazole Compounds as Immunomodulators | PDCD1, CD274, PDCD1LG2 | REN 4533/4885RAB9A 4082/4885ACE 3762/4885 |
| US-20180044303-A1 | 1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | PDCD1, PDCD1LG2, CD274 | REN 4666/4885RAB9A 4205/4885ACE 3938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.