Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12858794 | 0.86 | MAPT (0.49) | MAPK1ALDH1A1POLBSMN1; SMN2QPCT | |
| SCHEMBL318089 | 0.75 | KIF11 (0.41) | ALDH1A1ALOX15SMN1; SMN2LMNAKMT2A | |
| SCHEMBL18078939 | 0.75 | MAPK1 (0.60) | MAPK1ALDH1A1 | |
| SCHEMBL31229543 | 0.73 | KDM4E (0.49) | ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL10102945 | 0.73 | KDM4E (0.49) | ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL14208120 | 0.72 | CNR1 (0.39) | LMNA | |
| SCHEMBL10102949 | 0.72 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10640127 | 0.72 | CBFB (0.41) | ALDH1A1ALOX15 | |
| SCHEMBL264426 | 0.72 | ATM (0.41) | ALDH1A1BRD4POLBSMN1; SMN2KMT2A | |
| SCHEMBL13614187 | 0.71 | IP6K1 (0.43) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144704-A2 | HETEROCYCLIC AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2016-09-15 | — | — | WO | disclosed |