Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 1.00 |
| ▸ | NPC1 | O15118 | 10/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 1.00 |
| ▸ | HTT | P42858 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18079712 | 0.85 | SMN1; SMN2 (0.73) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL18080850 | 0.85 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL18079721 | 0.81 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL18079701 | 0.80 | SLC1A2 (0.76) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL14685055 | 0.80 | SLC1A2 (1.00) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL16155555 | 0.80 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL30674412 | 0.80 | SLC1A2 (1.00) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL18079709 | 0.80 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL18079702 | 0.80 | SLC1A2 (0.71) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL13052131 | 0.78 | KDM4E (0.72) | RAB9ANPC1SMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |