Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.67 |
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | HTT | P42858 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14685052 | 0.91 | SMN1; SMN2 (0.65) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18079702 | 0.86 | SLC1A2 (0.71) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18080851 | 0.85 | SLC1A2 (0.67) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18079701 | 0.83 | SLC1A2 (0.76) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL16155555 | 0.83 | RAB9A (0.66) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18079711 | 0.81 | SMN1; SMN2 (0.52) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18080850 | 0.80 | RAB9A (0.74) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18079703 | 0.80 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18079716 | 0.79 | RAB9A (0.69) | RAB9ASMN1; SMN2NPC1HTTMEN1 | |
| SCHEMBL18080856 | 0.78 | RAB9A (0.63) | RAB9ASMN1; SMN2NPC1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |